The NIGMS Human Genetic Cell Repository is now offering a new collection of cell lines to support research into frontotemporal dementia (FTD), one of the most common forms of early-onset dementia. These lines represent individuals with clinically and genetically confirmed FTD and expand the repository’s resources for studying neurodegenerative diseases.
The new FTD collection includes fibroblast lines derived from donors with the Tau R406W mutation in the MAPT gene associated with the disorder. These well-characterized cell lines provide researchers with reliable tools to model disease mechanisms, explore pathogenic pathways, and evaluate potential therapeutic targets.
By increasing access to disease-relevant cellular models, the NIGMS Repository continues to promote discovery in neuroscience and translational research. These FTD lines offer a valuable platform for studying the genetic and molecular basis of dementia and for accelerating the development of new treatment strategies.
A full list of frontotemporal dementia lines available through the NIGMS Catalog can be found here:
