Differentiated Cell Lines

At the Coriell Institute, we specialize in the differentiation of induced pluripotent stem cells (iPSCs) into various functional cell types, enabling cutting-edge research in disease modeling, drug discovery, and regenerative medicine. Our differentiated cell lines provide high-quality, reproducible cellular models that closely mimic in vivo physiology, making them invaluable tools for biomedical research.

Key Differentiated Cell Lines and Applications

• Cardiomyocytes: iPSCs reprogrammed from fibroblasts or PBMC are differentiated into cardiomyocytes, offering a physiologically relevant model for studying cardiac diseases, electrophysiology, and drug responses.
• Neurons: Differentiation into neuronal subtypes allows researchers to investigate neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s disease.
• Hepatocytes: iPSC-derived liver cells provide a robust platform for toxicology studies, drug metabolism research, and liver disease modeling.

Advancing Research with Differentiated iPSC Lines

The ability to generate patient-specific, genetically modified, and disease-relevant differentiated cells from iPSCs is transforming biomedical research. Coriell’s differentiated cell lines are driving innovations in:

Personalized Medicine	Enabling patient-specific drug testing and therapeutic development.
Gene Editing & Disease Modeling	Creating genetically engineered cell models for studying inherited disorders.
High-Throughput Drug Screening	Providing physiologically relevant models for assessing drug efficacy and toxicity.
Regenerative Medicine & Cell Therapies	Investigating potential therapeutic applications for tissue repair and transplantation.

By leveraging Coriell’s expertise in iPSC differentiation, researchers gain access to superior disease models, drug discovery platforms, and translational medicine applications, paving the way for the next generation of biomedical breakthroughs.

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