The NIGMS Repository now offers high-molecular-weight (HMW) DNA from an expanded range of source materials, including fibroblast and induced pluripotent stem cell (iPSC) lines. Many of these lines carry tandem repeat mutations or serve as reference materials, such as GM25256, providing valuable resources for genomic research.
In collaboration with PacBio, the Repository has optimized protocols for extracting HMW DNA from fibroblasts and iPSCs, ensuring high-quality samples for advanced sequencing applications. PacBio HiFi sequencing has been performed on select samples, with in-house quality control measures in place to maintain rigorous standards.
HMW DNA is available as catalog products and through an on-demand service, expanding access to high-quality genomic materials for researchers studying complex genetic variation and structural mutations.
