Data collected on these subjects consisted of Control Clinical Data Elements as outlined in the Coriell NINDS Genetics Repository guidelines. These data elements were developed to be consistent with other NIH healthy control sample collections including that of the National Institute on Aging Late Onset Alzheimer's Disease Consortium (LOAD). These data include a detailed medical and family history.

None of the subjects on the panel have a history of neurological illness in themselves. All were asked specifically regarding the following disorders, which were not present: Alzheimer's, amyotrophic lateral sclerosis, ataxia, autism, bipolar disorder, cerebrovascular disease (aneurysm and stroke), dementia, epilepsy, dystonia, migraine, multiple sclerosis, muscle disease, Parkinson's disease, schizophrenia, and Tourette syndrome. None have any first degree relative with a known primary neurological disorder. Specifically none have a family history of any first degree relative with any of the following disorders: Alzheimer's, amyotrophic lateral sclerosis, ataxia, autism, bipolar disorder, cerebrovascular disease (aneurysm and stroke), dementia, epilepsy, dystonia, migraine, multiple sclerosis, muscle disease, Parkinson's disease, and schizophrenia.

All samples and data were collected with informed consent under local IRB approved protocols. These samples are generously shared by Drs. John Hardy, Andrew Singleton, Karen Furie, Eric Sorenson, Petra Kaufmann, Robert Brown Jr., Edward Kasarskis, Catherine Lomen-Hoerth, Michael S. Okun, Ronald Mandel, Robert Miller, Alan Pestronk, Paul Gordon, Zbigniew Wzolek, Dennis Dickson, Catherine Lomen-Hoerth, Paul Gordon, Nickolas Maragakis, Zachary Simmons, James Meschia, Kapil Sethi, Merit Cudkowicz, James Russell, Katrina Gwinn, David Simon, Richard Bedlack, Eric Pioro, Peter Bosch, Paul Barkhaus, Richard Barohn, Gazala Hayat, and Okan Dogu.

Publications
Please cite the panel number and the NINDS Repository in any publications, and kindly share those references with the NINDS Repository Management Team at Coriell (NINDS@Coriell.org). Portions or all of this statement may be used in publications relevant to this panel.

Other Healthy Controls, Positive Controls
Control samples from individuals without neurological disease and with a range of clinical data are available via the NINDS Repository catalogue. Single samples from this panel can also be obtained, individually. Positive control samples for known causal genes are available, as listed, under specific disorders (see NINDS Repository catalog).