PARKINSON'S PANEL: WHITE FROM NORTH AMERICA
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Catalog ID: NDPT089
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Panel Composition and Demographics
Brief Description: This panel contains 5 µg DNA from 92 unique and unrelated White individuals from idiopathic Parkinson's disease (PD). These include 46 males and 46 females from the United States. The age of PD onset ranges from 56 to 87 years. This was defined as when symptom(s) of PD were first noted (including at least one: resting tremor, rigidity, bradykinesis, gait disorder, postural instability). NDPT089 Replaces NDPT018 and it has all of the same samples except: ND03092 replaces ND03433, and ND14583 replaces ND01749. Panel Design
The concentration of each DNA sample to be plated is normalized to 150 ng/ul and then this concentration is verified. The specific position on the plates has been randomized to reduce any possibility of systematic errors. Four wells remain empty for control samples from submitters, and two samples are present in two wells each (ND00010, A11 and E12; ND00132, F09 and G12) as internal controls. Diagnostic and Clinical Features
The phenotypic details of any single subject can be viewed through the list of panel members by clicking on the individual ID number. In order for subject inclusion, complete NINDS Repository Clinical Data Elements (CDEs) were required. Furthermore, only subjects who met the UK Brain Bank Criteria idiopathic Parkinson's disease were included (Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease. A clinico-pathological study of 100 cases. JNNP 1992;55:181-184.). By those criteria, all subjects had bradykinesia, and at least one of the following: 1) muscular rigidity; 2) 4-6 Hz resting tremor; 3) postural instability (not caused by primary visual, vestibular, cerebellar, or proprioceptive dysfunction). None had exclusionary features. All had documentation of sustained, excellent response to anti-parkinsonian therapy. All samples and data were collected with informed consent under local IRB approved protocols. These samples are generously shared by the clinical teams of Dr. David Simon, Okun Mandel, John Hardy, Dennis Dickson, Zbigniew Wszolek, Matthew Farrer, Kapil Sethi, Andrew Singleton, Ray Watts, Melissa Hanson, David Coffey, Robert Hauser, Ted Rothstein, Laura Marsh, Rodger Elble, Robert Hamill, Jayaraman Rao, Frederick Wooten, and Ira Shoulson. Family history
All subjects were queried regarding family history of parkinsonism, dementia, tremor, gait disorders, and other neurological dycfunction. Subjects both with and without a reported family history of Parkinson's disease were included on this panel. None were included who had three or more relatives with parkinsonism, nor with apparent Mendelian inheritance of PD. Additional family history data are available by viewing the excel file containing all the clinical data. Publications
Please cite the panel number and the NINDS Repository in any publications, and kindly share those references with the NINDS Repository Management Team at Coriell (NINDS@Coriell.org). Portions or all of this statement may be used in publications relevant to this panel. Other Samples, Positive Controls
Samples which may be useful as controls for this panel are additionally available via the NINDS Repository catalogue. Note that positive controls for synuclein triplication and parkin mutation, as well as individuals without Parkinson's or other neurological disease are also available.
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