Data collected on these subjects Clinical consist of the cerebrovascular disease (CVD) Clinical Data Elements, including primary clinical diagnosis (type of CVD), medical history for several CVD risk factors, and medical history for a number of other neurological disorders. The CDEs also include ischemic stroke subtype based on TOAST (Adams et al. 1993, Stroke 24[1]:35-41), as well as AVM subtype. Most researchers believe that CVD has complex environmental risk factors (Meschia 2003, The Lancet 2(8):459), and because of clinical and genetic complexity, the optimal phenotyping approach for CVD is not yet known. The CVD CDEs are designed to capture data that are, by an educated guess based on current information, useful for gene discovery. However, these are likely to change over time, and ideally should, as our knowledge of the genetics in these disorders increases.

Other than stroke, none of the subjects on the panel reported a history of any other neurological illness, and none have a family history that includes a primary blood relative with CVD. All samples and data were collected with informed consent under local IRB approved protocols. These samples are generously shared by Drs. Gregory Sorensen, Karen Furie, Lynda Lisabeth, and James Meschia.

Acknowledgement of the NINDS Repository in Publications

Please cite the panel number and the NINDS Repository in any publications, and share those references with the NINDS Repository Management Team at Coriell (NINDS@Coriell.org). Portions or all of this statement may be used in publications relevant to this panel.

Other Ischemic Stroke Samples

Additional ischemic stroke samples are available via the NINDS Repository catalogue, including the VISP Resource. Single samples from this panel can also be obtained, individually.