Panel Contributors
All samples and data were collected with informed consent under local IRB approved protocols. These samples are generously shared by Drs. Russell Buono, Petra Kaufman, Eric Sorenson, Catherine Lomen-Hoerth, David Simon, John Hardy, Robert Brown, Okun Mandel, Micheline Gravel, Peter Bosch, Paul Gordon, Dennis Dickson, Zbigniew Wszolek, Matthew Farrer, Daniel Newman, Laura Sams, Angela Gresham, Edward Kasarskis, Kapil Sethi, Frederick Wooten, Anthony Crawley, Nickolas Maragakis, Robert Miller, Robert Hamill, Jayaraman Rao, Burton Scott, Ray Watts, and Kevin Boylan. Brief Description
This panel contains 5 micrograms of DNA/well from 92 unique and unrelated White individuals without neurological disorders. Of these, 27 are males and 65 females, with an age range at collection from 36-48 years. All are from North America. Four wells remain empty for additional laboratory controls.
Data collected on these subjects consisted of Control Clinical Data Elements as outlined in the Coriell NINDS Genetics Repository guidelines. These data elements were developed to be consistent with other NIH healthy control sample collections including that of the National Institute on Aging Late Onset Alzheimer's Disease Consortium (LOAD). These data include a detailed medical and family history.
None of the subjects on the panel have a history of neurological illness in themselves. All were asked specifically regarding the following disorders, which were not present: Alzheimer's, amyotrophic lateral sclerosis, ataxia, autism, bipolar disorder, cerebrovascular disease, dementia, dystonia, Parkinson's, and schizophrenia. None have any first degree relative with a known primary neurological disorder. Specifically none have a family history of any first degree relative with any of the following disorders: amyotrophic lateral sclerosis, ataxia, autism, cerebrovascular disease, dystonia, Parkinsons, schizophrenia.
Publications
Please cite the panel number and the NINDS Repository in any publications, and share those references with the NINDS Repository Management Team at Coriell (NINDS@Coriell.org). Portions or all of this statement may be used in publications relevant to this panel.
Other Healthy Controls, Positive Controls
Additional control samples from individuals without neurological disease and with a range of clinical data are available via the NINDS Repository catalogue. Single samples from this panel can also be obtained, individually. Positive control samples for known causal genes are available, as listed, under specific disorders.