AG09309

AG09309 Fibroblast from Skin, Toe

Description:

APPARENTLY HEALTHY INDIVIDUAL

Affected:

No

Sex:

Female

Age:

21 YR (At Sampling)

Overview

Repository

NIA Aging Cell Culture Repository

Subcollection

Apparently Healthy Collection

Biopsy Source

Toe

Cell Type

Fibroblast

Tissue Type

Skin

Transformant

Untransformed

Sample Source

Fibroblast from Skin, Toe

Race

White

Relation to Proband

proband

Confirmation

Clinical summary/Case history

Species

Homo sapiens

Common Name

Human

Remarks

The culture was initiated on 1/14/87 from explants of minced skin tissue removed ante-mortem from a donor being treated for an ingrown toenail. The cell morphology is fibroblast-like and the karyotype is 46,XX with 7% of the cells examined showing random chromosome loss/gain. Same donor as AG28869 (iPSC); The legacy karyotype description shown in this Remark may not be representative of the current available product.

Characterizations

PDL at Freeze

6.69

Passage Frozen

IDENTIFICATION OF SPECIES OF ORIGIN

Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis

Phenotypic Data

Remarks

Publications

Della Valle F, Reddy P, Yamamoto M, Liu P, Saera-Vila A, Bensaddek D, Zhang H, Prieto Martinez J, Abassi L, Celii M, Ocampo A, Nuñez Delicado E, Mangiavacchi A, Aiese Cigliano R, Rodriguez Esteban C, Horvath S, Izpisua Belmonte JC, Orlando V, LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes Science translational medicine14:eabl6057 2022

PubMed ID: 35947677

Varlet AA, Desgrouas C, Jebane C, Bonello-Palot N, Bourgeois P, Levy N, Helfer E, Dubois N, Valero R, Badens C, Beliard S, A Rare Mutation in Cells11:eabl6057 2021

PubMed ID: 35011612

Desgrouas C, Varlet AA, Dutour A, Galant D, Merono F, Bonello-Palot N, Bourgeois P, Lasbleiz A, Petitjean C, Ancel P, Levy N, Badens C, Gaborit B, Unraveling Cells9:eabl6057 2019

PubMed ID: 32012908

Nguyen C, Baskaran K, Pupulin A, Ruvinov I, Zaitoon O, Grewal S, Scaria B, Mehaidli A, Vegh C, Pandey S, Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics BMC complementary and alternative medicine19:98 2019

PubMed ID: 31060537

Oeste CL, Pinar M, Schink KO, Martínez-Turrión J, Stenmark H, Peñalva MA, Pérez-Sala D, An isoprenylation and palmitoylation motif promotes intraluminal vesicle delivery of proteins in cells from distant species PloS one9:e107190 2014

PubMed ID: 25207810

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Dechat T, Shimi T, Adam SA, Rusinol AE, Andres DA, Spielmann HP, Sinensky MS, Goldman RD, Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging Proceedings of the National Academy of Sciences of the United States of America104:4955-60 2007

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