GM03164
LCL from B-Lymphocyte
Description:
HLA HISTOCOMPATIBILITY TYPE: 142800 THROUGH 142860 & 142880
|
Repository
|
NIGMS Human Genetic Cell Repository
|
| Subcollection |
Heritable Diseases |
|
Biopsy Source
|
Peripheral vein
|
|
Cell Type
|
B-Lymphocyte
|
|
Tissue Type
|
Blood
|
|
Transformant
|
Epstein-Barr Virus
|
|
Sample Source
|
LCL from B-Lymphocyte
|
|
Relation to Proband
|
proband
|
|
Confirmation
|
Clinical summary/Case history
|
|
Species
|
Homo sapiens
|
|
Common Name
|
Human
|
|
Remarks
|
|
| HLA TYPING |
HLA type; A:2,24; B:27; C:2; D:4; DR:4,4 |
| |
| Remarks |
HLA type; A:2,24,B:27,C:2,D:4,DR:4,4 line AS |
| Woulfe SL, Bono CP, Zacheis ML, Welply JK, Kirschmann DA, Baudino TA, Wang Y, Stone DA, Hanson GJ, Vuletich JL, Bedell LJ, Schwartz BD, Howard SC, A peptidomimetic that specifically inhibits human leukocyte antigen DRB1*0401-restricted T cell proliferation. J Pharmacol Exp Ther281:663-9 1997 |
| PubMed ID: 9152371 |
| |
| Kirschmann DA, De Ciechi PA, Bono CP, Zacheis ML, Schwartz BD, Woulfe SL, Utilization of soluble fusion proteins for induction of T cell proliferation. Cell Immunol160:193-8 1995 |
| PubMed ID: 7720079 |
| |
| Kirschmann DA, Duffin KL, Smith CE, Welply JK, Howard SC, Schwartz BD, Woulfe SL, Naturally processed peptides from rheumatoid arthritis associated and non-associated HLA-DR alleles. J Immunol155:5655-62 1995 |
| PubMed ID: 7499850 |
| |
| Woulfe SL, Bono CP, Zacheis ML, Kirschmann DA, Baudino TA, Swearingen C, Karr RW, Schwartz BD, Negatively charged residues interacting with the p4 pocket confer binding specificity to DRB1*0401. Arthritis Rheum38:1744-53 1995 |
| PubMed ID: 8849346 |
| |
| Cole JL, Housley GA Jr, Dykman TR, MacDermott RP, Atkinson JP, Identification of an additional class of C3-binding membrane proteins of human peripheral blood leukocytes and cell lines. Proc Natl Acad Sci U S A82:859-63 1985 |
| PubMed ID: 3871945 |
| |
| Giles RC, DeMars R, Chang CC, Capra JD, Allelic polymorphism and transassociation of molecules encoded by the HLA-DQ subregion. Proc Natl Acad Sci U S A82:1776-80 1985 |
| PubMed ID: 3856859 |
| |
| Walker LE, Ketler TA, Houghten RA, Schulz G, Chersi A, Reisfeld RA, Human major histocompatibility complex class I antigens: residues 61-83 of the HLA-B7 heavy chain specify an alloreactive site. Proc Natl Acad Sci U S A82:539-42 1985 |
| PubMed ID: 3881768 |
| |
| Brodsky FM, A matrix approach to human class II histocompatibility antigens: reactions of four monoclonal antibodies with the products of nine haplotypes. Immunogenetics19:179-194 1984 |
| PubMed ID: 6200433 |
| |
| Sant AJ, Cullen SE, Schwartz BD, Identification of a sulfate-bearing molecule associated with HLA class II antigens. Proc Natl Acad Sci U S A81:1534-8 1984 |
| PubMed ID: 6424118 |
| |
| Shipp MA, Schwartz BD, Kannapell CC, Griffith RC, Scott MG, Ahmed P, Davie JM, Nahm MH, A unique DR-related B cell differentiation antigen. J Immunol131:2458-67 1983 |
| PubMed ID: 6415171 |
| |
| Finn OJ, Levy R, Multiple HLA-DR antigens: detection with monoclonal antibodies and translation in vitro. Proc Natl Acad Sci U S A79:2658-62 1982 |
| PubMed ID: 6979750 |
| dbSNP |
dbSNP ID: 16809 |
| Gene Cards |
HLA-A |
|
HLA-DPA1 |
|
HLA-DRA |
| Gene Ontology |
GO:0005887 integral to plasma membrane |
|
GO:0006955 immune response |
|
GO:0019883 antigen presentation, endogenous antigen |
|
GO:0019884 antigen presentation, exogenous antigen |
|
GO:0019885 antigen processing, endogenous antigen via MHC class I |
|
GO:0019886 antigen processing, exogenous antigen via MHC class II |
|
GO:0030106 MHC class I receptor activity |
|
GO:0045012 MHC class II receptor activity |
| NCBI Gene |
Gene ID:3105 |
|
Gene ID:3113 |
|
Gene ID:3122 |
| NCBI GTR |
142800 MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, A; HLA-A |
|
142860 MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR ALPHA; HLA-DRA |
|
142880 MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DP ALPHA-1; HLA-DPA1 |
| OMIM |
142800 MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, A; HLA-A |
|
142860 MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR ALPHA; HLA-DRA |
|
142880 MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DP ALPHA-1; HLA-DPA1 |
| Omim Description |
HLA-A HISTOCOMPATIBILITY TYPE |
| |
MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, A; HLA-A |
| |
HLA-DR HISTOCOMPATIBILITY TYPE; HLA-DRA |
| |
MAJOR HISTOCOMPATIBILITY COMPLEX II, DR ALPHA; HLA-DRA1 |
| |
HLA-SB HISTOCOMPATIBILITY TYPE; HLASB; HLADP |
| |
MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DP ALPHA-1; HLA-DPA1 |
| Split Ratio |
1:5 |
| Temperature |
37 C |
| Percent CO2 |
5% |
| Medium |
Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent |
| Serum |
15% fetal bovine serum Not Inactivated |
| Substrate |
None specified |
| Subcultivation Method |
dilution - add fresh medium |
| Supplement |
- |
|
|